Post-Doctoral Positions - Next-generation Single-molecule, Super-resolution Optical Imaging and In situ Structural Biology Approaches
Memorial Sloan Kettering Cancer Center
Location: New York, New York
Internal Number: 64918
Memorial Sloan Kettering Cancer Center (MSK) is one of the world's premier cancer centers, committed to exceptional patient care, leading-edge research, and superb educational programs. The blending of research with patient care is at the heart of everything we do. The institution is a comprehensive cancer center whose purposes are the treatment and control of cancer, the advancement of biomedical knowledge through laboratory and clinical research, and the training of scientists, physicians, and other health care workers.
The Pertsinidis lab in the Structural Biology Program of the Sloan Kettering Institute at MSKCC
has immediate openings for Postdoctoral positions.
A major focus in our lab is developing cutting-edge single-molecule detection and superresolution
optical imaging techniques. We further apply the tools we develop to visualize and
understand some of the most fundamental biological processes that power cellular life. For
example, our lab has developed modulation interferometry, a single-molecule localization-based
super-resolution technique with ~1-2 nm 3D precision and target-locking 3D nanoscopy, a
technique that achieved single-molecule detection in high background, crowded intracellular
environments. These tools have enabled some of the highest resolution single-molecule studies
to date, providing new biological insights that could not be obtained before (e.g. Wang et al. Cell
2016; Li et al., Cell 2019).
Successful applicants will become an important member of our vibrant, interdisciplinary team of
physical and biological scientists. We now develop the next-generation of low-background, noninvasive
and photon-efficient techniques - to further enhance our ability to visualize biological
processes in live cells with single-molecule sensitivity, (sub)-millisecond temporal and (sub)-
nanometer 3D spatial resolution. We also further push the limits of extracting high-resolution
information from weak signals in optically inhomogeneous, thick, multi-cellular environments,
such as tissue explants, 3D organoids and the developing embryo. Finally, we develop new
single-molecule imaging and machine learning technologies for in situ structural
biology, to enable for the first time high-resolution structural studies inside cells.
* Desire to tackle outstanding challenges in optics, microscopy and/or single-molecule
* Ph.D. degree in Physics, Chemistry, Optics, Optical Engineering, Biophysics or a
relevant scientific or engineering field.
* Ability to work effectively in a collaborative, multidisciplinary environment.
Experience with single-molecule detection instrumentation and high/super-resolution optical
etc.), as well as cryogenic and UHV technologies is preferred but not required. Individuals with
additional working knowledge in areas of biochemistry, molecular, cell and developmental
biology and/or genetics are strongly encouraged to apply.
Please send a CV, names and contact
information of three references, and a short description of scientific interests to Dr. Alexandros
MSK is an equal opportunity and affirmative action employer committed to diversity and inclusion in all aspects of recruiting and employment. All qualified individuals are encouraged to apply and will receive consideration without regard to race, color, gender, gender identity or expression, sexual orientation, national origin, age, religion, creed, disability, veteran status or any other factor which cannot lawfully be used as a basis for an employment decision.
Federal law requires employers to provide reasonable accommodation to qualified individuals with disabilities. Please tell us if you require a reasonable accommodation to apply for a job or to perform your job. Examples of reasonable accommodation include making a change to the application process or work procedures, providing documents in an alternate format, using a sign language interpreter, or using specialized equipment.
At Memorial Sloan Kettering (MSK), we’re not only changing the way we treat cancer, but also the way the world thinks about it. By working together and pushing forward with innovation and discovery, we’re driving excellence and improving outcomes. For the 28th year, MSK has been named a top hospital for cancer by U.S. News & World Report. We are proud to be on Becker’s Healthcare list as one of the 150 Great Places to Work in Healthcare in 2018, as well as one of Glassdoor’s Employees’ Choice Best Place to Work for 2018. We’re treating cancer, one patient at a time. Join us and make a difference every day.