Our research studieshow activity leads to functional and structural alterations in neuronal microcircuits and how these enable learning and memory.
The successful candidate will join us for a fully funded position and will apply advanced optical methods (such as 2-photon microscopy, glutamate uncaging, calcium imaging) to manipulate and follow activity at single or groups of dendritic spines ex vivo, as well as identify corresponding functional changes. The long lasting storage of information requires local activation of signaling events and structural changes which together allow for synaptic plasticity that can last a lifetime. Thus, the project combines optical probing of hippocampal (and other) circuits with electrophysiological recordings and biochemical approaches. The goal is to elucidate fundamental learning rules and how they are encoded at synapses, as well as to identifycritical points of dysfunction that impact cognitive function. We leverage the power of mouse genetics to understand how mutations leading tohuman disorders underlie changes in synaptic function across the lifespan, from Autism to Alzheimer's Disease.
The Israely Laboratory of Neuronal Structure and Function is located at Columbia University's Irving Medical Center in the city of New York. We are a part of the Department of Pathology & Cell Biology and the Department of Neuroscience, in the Taub Institute on Alzheimer's Disease and the Aging Brain.
The person must be able to work independently, analyze and present data, and be proactive in solving problems. Familiarity with multiphoton calcium imaging, electrophysiology, and basic programming knowledge (Matlab) is highly advantageous. The person should also contribute towards building an exciting scientific environment with positive leadership skills. Good communication and writing skills are essential.
The ideal candidate will be a highly motivated holder of a PhD (or equivalent) degree, with experience in at least one or more fields of: neuroscience, physiology, biochemistry, cell biology, biomedical or optical engineering or similar disciplines. Applicants with backgrounds in related fields (such as physics or computer science) with an interest in neuroscience are encouraged to apply, and should provide a cover letter explaining their motivation.
Ultimately, the successful candidate will be passionate about discovering how the brain works!
Our lab has ongoing collaborations with many outstanding neuroscientists within the Columbia community, including within the Taub Institute, the Center for Translational Neuroscience Initiative, and at the Zuckerman Institute for Mind, Brain, and Behavior (of which we are an affiliate lab).
For consideration and more information, qualified applicants should send a cover letter detailing their background, current work, and future research interests, along with a CV and references to firstname.lastname@example.org.
Columbia University is an Equal Opportunity Employer / Disability / Veteran
Columbia University is one of the world's most important centers of research and at the same time a distinctive and distinguished learning environment for undergraduates and graduate students in many scholarly and professional fields. The University recognizes the importance of its location in New York City and seeks to link its research and teaching to the vast resources of a great metropolis. It seeks to attract a diverse and international faculty and student body, to support research and teaching on global issues, and to create academic relationships with many countries and regions. It expects all areas of the university to advance knowledge and learning at the highest level and to convey the products of its efforts to the world.