We are currently recruiting for a Research Engineer or Software Engineer I, II or III with strong computational skills and preferably experience with Machine Learning (ML) to work on a very ambitious project to uncover disease mechanisms of Amyotrophic Lateral Sclerosis (ALS), Huntingtonâ™s Disease (HD) or Parkinsonâ™s Disease (PD) using sophisticated image analysis tools.Â The person in this position will develop computational methods to extract features from iPSC-derived neurons from patients with ALS, PD or HD that will elucidate molecular mechanisms of neurodegenerative disease. Â This person will also help use ML techniques to analyze genomic data to help understand the disease- causing variants of ALS, PD and HD using Whole Genome Sequence (WGS) data.
At the core of our research is a novel robotic microscope system that we have invented to collect images and time-lapse movies of fluorescently-labeled neurons in high-throughput format. We use our microscopy system to extract various types of biological information about how patient-derived neurons with neurological disease variants grow, connect and behave. This person will help to run and develop our image analysis-based algorithms to capture phenotypes and will help to use ML tools using Deep Learning and Supervised Machine Learning to train models to recognize certain cellular features of ALS, HD and PD. This person will also have the opportunity to work with WGS data to develop genetic risk scores using ML as well.
Programming experience in Python, Java and R
Statistical skills: exploratory data analysis
Machine Learning libraries like TensorFlow, Keras or Scikit-Learn
Experience with genomics
Internal Number: REQ-944
About Gladstone Institutes
The Gladstone Institutes is an independent, not-for-profit research institution affiliated with the University of California San Francisco (UCSF), transforming the health and well-being of all people through medical research, education, and outreach in the fields focused on heart disease, immunology and virology including HIV/AIDS, and neurological disease. Home to notable leaders in the field of medical science, including 2012 Nobel Prize in Physiology or Medicine recipient Shinya Yamanaka, M.D.,Ph.D. Gladstone is comprised of four institutes in addition to various Centers and programs focusing approximately 500 members of our team on its mission: Science Overcoming Disease. Located in an award-winning building adjacent to UCSF's Mission Bay Campus, Gladstone offers a competitive salary and benefits program within a robust environment for those seeking to maximize their potential. Please consider Gladstone and make a difference in human health.