The emergence of new optical technologies combined with molecular sensors and advanced computational tools have led to major advances of our understanding of how the circuitry and dynamics of neuronal population give rise to brain functions and behavior. The Vaziri Lab of Neurotechnology and Biophysics (LNB) has a major focus on the development and application of advanced optical imaging technologies with applications for systems neuroscience. Over the last few years the lab has developed a portfolio of optical techniques that allow near-simultaneous stimulation [1, 2] and functional imaging of neuronal activity on the whole-brain level at single-cell level in small model organisms [3, 4] and more recently in the more scattering rodent brain [5-8].
To further push the boundaries of neurotechnology development and brain-imaging, we are seeking to fill the position of (Senior) Staff Scientist / (Senior) Research Associate in the LNB who can develop an independent and highly synergistic research program aligned with the ongoing efforts in the laboratory. The successful candidate will be imbedded in LNB benefiting from the existing laboratory infrastructure and scientific environment while leading a team supported by independently as well as jointly acquired external funding. Possible areas of the focus of the research program of the applicants may include but are not limited to:
Development of new optical or non-optical methods for interrogating neuroactivity
Imaging through scattering media
Computational imaging technologies, machine learning and advanced statistics
Development of early stage technologies for bioimaging and biology based on conceptually new approaches from quantum optics/quantum sensing, ultrafast optics, nano-photonics or other areas
Development of new molecular sensors and use of biochemical or synthetic biological approaches
Highly motivated, ambitious and goal-driven
PhD in physics, (quantum) optics, optical / electrical engineering, synthetic biology or neuroscience
Demonstrated scientific excellence and substantial contributions in research in candidate’s field
Ability to manage multiple tasks and projects and work as a key part of an interdisciplinary team, excellent organizational and communication skills and willingness to work outside their core expertise.
Prior experimental work on one and more of these areas highly desired: designing and building optical setups, ultra-fast optics, fiber optics, computational modeling, systems neuroscience, animal surgery or behavior
Support multiple research projects at the senior level, lead own independent projects while training and mentoring other more junior scientists
Support Head of Laboratory with execution of the laboratory research program and acquisition of external funding that would support the lab and their own projects
Author, publish, and present research findings
As needed, serve as a liaison to industry and support the dissemination of developed technologies
After an initial appointment period, candidates can be considered for possible appointment as a Research Assistant Professor. This appointment requires successful review by a university committee. Interested candidates should send their CV including a list of publications, a statement of research interests and accomplishments as well as the contact information of at least three references to email@example.com For more information please visit our website www.vaziria.com
Andrasfalvy, B., et al., Two-photon Single Cell Optogenetic Control of Neuronal Activity by Sculpted Light.PNAS, (2010). 107.
Losonczy, A., et al., Network mechanisms of theta related neuronal activity in hippocampal CA1 pyramidal neurons.Nature Neuroscience, (2010). 13(8): p. 967-72.
Schrodel, T., et al., Brain-wide 3D imaging of neuronal activity in Caenorhabditis elegans with sculpted light.Nature Methods, (2013). 10(10): p. 1013-1020.
Prevedel, R., et al., Simultaneous whole-animal 3D imaging of neuronal activity using light-field microscopy.Nature Methods, (2014). 11(7): p. 727-730
Robert, R. et al., Fast volumetric calcium imaging across multiple cortical layers using sculpted light. Nature Methods, (2016) 13, 1021-1028
Skocek,O., et al., High-speed volumetric imaging of neuronal activity in freely moving rodents. Nature Methods, (2018). 15, 429–432.
Nöbauer, T., et al., Video rate volumetric Ca2+ imaging across cortex using seeded iterative demixing (SID) microscopy. Nature Methods, (2017).14, 811-81.
Weisenburger, S. et al., Volumetric Ca2+ Imaging in the Mouse Brain using Hybrid Multiplexed Sculpted Light (HyMS) Microscopy. Cell (2019), in press
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