OverviewIn vivo microscopy (IVM) is a new field where microscopic images are acquired from living human tissue. As a result of advancements such as massive increases in imaging speed, these technologies are now capable of evaluating the three-dimensional microstructure of entire organs within the body. These developments make it possible to comprehensively screen for disease using microscopic morphology in a manner that far exceeds the diagnostic yield of conventional biopsy. Many such IVM devices are commercially available and being used clinically. Since pathologists are expertly trained in microscopic morphology, there has been a push to increase pathologist involvement for interpreting IVM images clinically.In addition, many IVM technologies are being explored for use in surgical pathology processing including the rapid determination of tumor positive margins and assessment of specimen adequacy prior to molecular/genomic analysis. IVM technology used for surgical specimens has been named ex vivo microscopy (EVM) and represents a major potential area for growth in the field of anatomic pathology.The objectives of this one-year research fellowship are to train a pathology fellow on the use of IVM/EVM and the interpretation of IVM/EVM images, the generation of reference materials for IVM/EVM, and the development of training and signout programs for IVM and EVM. The fellowship will be performed in the laboratory of and under the supervision of Dr. Guillermo Tearney, MD PhD, a pioneer in IVM who has developed many of the technologies that are used in practice today as well as validated diagnostic algorithms for interpreting images obtained by these devices. After this IVM research fellowship is completed, trainees will have a broad knowledge of IVM technology and IVM image interpretation as well as the skills required to continue research in IVM and participate in growing the clinical IVM field for pathologists world wide.Types and Number of AppointmentsThe fellowship is for one year. It is possible, however, for fellows will be accepted before they are Board eligible. Such candidates should present compelling reasons that the fellowship should be done prior to finishing residency, and have concrete plans for finishing their pathology residency training.CurriculumThis IVM research fellowship is comprised of the following items:1)Learn how to use IVM/EVM devices and interpret IVM/EVM images2)Participate in selected IVM procedures at MGH3)Assist with writing a IVM GI Pathology atlas4)Develop IVM signout service at MGH5)Assist with College of American Pathologists (CAP) IVM Committee initiatives, including helping to develop training materials, checklists, and proficiency testing for IVM6)Curriculum development for future IVM fellowships? Structure of the ProgramThe IVM Fellow will work directly with Dr. Tearney under his supervision. The Fellow will participate in IVM/EVM research projects as well as work on topics listed in the Curriculum above. The IVM Fellow will meet with Dr. Tearney weekly to discuss research project progress as well as career mentoring. In addition, the Fellow will attend CAP IVM committee teleconference calls and face-to-face meetings during the fellowship year. The fellow will also participate in local and national meetings and conferences on IVM/EVM.FacultyThe primary faculty for this research fellowship will be Dr. Tearney. In addition, the fellow will frequently interact with other IVM pathologists at MGH, including Drs. Gregory Lauwers (MGH Pathology Vice Chairman) and Lida Hariri (Pulmonary Pathologist at MGH) who are also skilled in IVM. StipendsFellows are paid according to their PGY level. Travel and book allowances are provided. Health insurance, long-term disability and life insurance are provided at a reasonable cost.ApplicationsPlease submit applications by May 1, as fellowships usually begin on July 1. Interested candidates should contact the Program Director, Guillermo Tearney at the address/email provided below. Applicants should send a completed CAP standardized Application for Pathology Fellowships, a CV, a copy of their USMLE transcript, a one-page personal statement concerning their interest in IVM/EVM, and three letters of reference (including one from their residency program director or department chief) to:IVM Fellowship Program AdministratorMassachusetts General Hospital55 Fruit Street, BHX604Boston, Massachusetts 02114-2352Phone: 617-724-2979 Fax: 617-726-4103 Email: MGHIVMFellows@partners.org Program Director?Guillermo Tearney, MD, PhD
RequirementsCompletion of residency training in anatomic or combined anatomic/clinical pathology, with primary certification or eligibility by the American Board of Pathology. For interntational candidates, a valid ECFMG certificate and visa are required.
Guillermo (Gary) Tearney M.D., Ph.D. is a Mike and Sue Hazard Family MGH Research Scholar, Professor of Pathology at Harvard Medical School, an Affiliated Faculty member of the Harvard-MIT Division of Health Sciences and Technology (HST), and maintains his lab at the Wellman Center for Photomedicine at the Massachusetts General Hospital. Prof. Tearney received his MD magna cum laude from Harvard M...edical School and received his PhD in Electrical Engineering and Computer Science from the Massachusetts Institute of Technology.
Prof. Tearney’s research interests are focused on the development and clinical validation of non-invasive, high-resolution optical imaging methods for disease diagnosis. Prof. Tearney’s lab was the first to perform human imaging in the coronary arteries and gastrointestinal tract in vivo with Optical Coherence Tomography (OCT), which provides cross-sectional images of tissue architectural microstructure at a resolution of 10 µm. He has also conducted many of the seminal studies validating OCT and is considered an expert on OCT image interpretation. Recently, Prof. Tearney’s lab has invented a next generation OCT technology, termed µOCT, which has a resolution of 1 µm and is capable of imaging cells and sub cellular structures in the coronary wall.
Prof. Tearney has also developed several other technologies, including a confocal endomicroscope capable of imaging the entire esophagus, an ultraminiature three-dimensional endoscope, a highly efficient form of near field scanning optical microscopy (NSOM), and novel fluorescence spectroscopy and multimodality imaging techniques. He has an active program in Raman spectroscopy and has conducted the first intracoronary Raman in vivo. Prof. Tearney is co-editor of The Handbook of Optical Coherence Tomography and has written over 170 peer-reviewed publications, including papers that have been highlighted on the covers of Science, Nature Medicine, Circulation, Gastroenterology, and Journal of American College of Cardiology.
Prof. Tearney has over 400 patent applications (~100 granted) and licenses on more than 200 patents/applications resulting in commercial medical devices. In addition, Dr. Tearney has served as principal investigator on over 40 grants, including NIH R01’s from the NCI, NIBIB, NHLBI, and NIDDK.
Prof. Tearney’s work extends beyond his laboratory at MGH, many of his technologies are being produced commercially, he is a member of the Scientific Advisory Board for; Massachusetts Life Sciences Center, the Clinical Advisory Board for; NinePoint Medical and he has founded the International Working Group on Intracoronary OCT Standardization and Validation, a group that is dedicated to establishing standards to ensure the widespread adoption of this imaging technology.